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Observe Intently (one)pentobarbital will lessen the level or outcome of fentanyl transmucosal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the reduce in fentanyl plasma concentrations, lack of efficacy or, quite possibly, improvement of the